WALCZAK GROUP AT THE UNIVERSITY OF COLORADO BOULDER

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POSTDOCTORAL ASSOCIATES

We welcome applications from qualified and highly motivated candidates for Postdoctoral Associate positions. To apply, please submit the following documents:

• A cover letter expressing your interest in the position.

• An updated CV showcasing your qualifications and experience.

• Arrange for at least two letters of recommendation.

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Open Positions. The Walczak Lab is seeking a highly motivated and creative Postdoctoral Researcher to join our multidisciplinary team focused on the molecular mechanisms of neurodegeneration. Our research integrates chemical biology, protein biochemistry, and stem cell-based models to uncover how pathogenic proteins contribute to diseases such as Alzheimer’s and frontotemporal dementia.

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Position Summary: The successful candidate will lead a project involving human iPSC-derived models to study proteinopathies, including tau and other proteins implicated in neurodegenerative diseases. The position will involve differentiation of stem cells into neuronal and glial subtypes, gene editing, advanced imaging, and proteomics to investigate protein aggregation, post-translational modifications, and cellular phenotypes linked to disease.

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Key Responsibilities:

• Culture and differentiate human iPSCs into neuronal and glial lineages

• Perform molecular and biochemical characterization of protein aggregation and clearance

• Utilize gene editing to generate disease-relevant models

• Collaborate with biophysicists, chemists, and neuroscientists within and outside the lab

• Prepare manuscripts and present findings at scientific conferences

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Qualifications:

• Ph.D. in cell biology, neuroscience, molecular biology, or related field

• Experience with stem cell or mammalian cell cultures

• Familiarity with neurodegenerative disease models and protein aggregation mechanisms preferred

• Excellent communication, teamwork, and problem-solving skills

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The Walczak Lab provides a collaborative and supportive environment for advancing translational research in neurodegeneration. Our group offers access to cutting-edge instrumentation, strong mentoring, and opportunities for interdisciplinary collaborations within CU Boulder and beyond.

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How to Apply: Please send a cover letter, CV, and contact information for two references to maciej.walczak@colorado.edu. Review of applications will begin immediately and continue until the position is filled.

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GRADUATE STUDENTS

Our research group is always excited to welcome enthusiastic and motivated graduate students. If you're interested in joining our group, please follow these steps:

• Visit the University of Colorado website for detailed admission information.

• If you are already a graduate student at CU, please reach out to Dr. Walczak via email to discuss potential research opportunities in our lab.

• Prospective students are also encouraged to contact our current graduate students to learn more about ongoing projects or check our projects website for more information.

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RESEARCH TECHNICIANS 

We invite applications from qualified candidates holding a BS (or MS) degree, along with a minimum of one year of relevant experience, for the Research Technician role.

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Open Positions. The Walczak Lab is seeking a full-time Professional Research Assistant to support ongoing projects in stem cell biology and neurodegenerative disease modeling. Our lab investigates the molecular mechanisms underlying protein misfolding in disorders such as Alzheimer’s disease, ALS, and frontotemporal dementia. We use cutting-edge stem cell technologies to generate disease-relevant human neuronal and glial models.

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Position Summary. The successful candidate will work closely with postdoctoral researchers and graduate students to maintain and differentiate human induced pluripotent stem cells (iPSCs), perform basic molecular biology assays, and assist with general lab organization. This is an excellent opportunity for someone interested in gaining hands-on experience in stem cell biology and neuroscience in a collaborative and fast-paced research environment.

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Key Responsibilities:

• Culture and maintenance of human iPSCs under sterile conditions

• Directed differentiation into neurons and/or glia

• Basic molecular biology techniques (PCR, Western blotting, immunocytochemistry)

• Assisting with imaging, sample preparation, and data organization

• Routine lab maintenance, inventory, and ordering supplies​​

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Required Qualifications:

• B.A./B.S. or M.S. in biology, neuroscience, molecular biology, or related field

• At least 1 year of laboratory experience (can include undergraduate research)

• Familiarity with sterile technique and cell culture practices

• Strong organizational skills, attention to detail, and willingness to learn​

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​​Preferred Qualifications:

• Experience with human iPSC culture and differentiation

• Familiarity with fluorescence microscopy and/or molecular cloning

• Interest in neurodegeneration or stem cell modeling​​

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​Benefits and Environment

• Full-time position with benefits through the University of Colorado system

• Training and mentorship opportunities for career development

• Access to state-of-the-art stem cell, imaging, and proteomics core facilities

• Friendly, inclusive, and intellectually engaging lab culture

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How to Apply: Please send a cover letter, CV, and contact information for two references to maciej.walczak@colorado.edu. Review of applications will begin immediately and continue until the position is filled.

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UNDERGRADUATE STUDENTS

For undergraduate students interested in conducting research in the Walczak group, please contact Dr. Walczak directly via email. Be sure to include your CV when reaching out.

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